Leon Cruveilhier

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Léon Jean Baptiste Cruveilhier (1791-1874), an influential French pathologist and Professor of Anatomy at Paris, described, but not as a distinct disease, multiple sclerosis in 1842, and contributed heavily to the concept of phlebitis which he over emphasized as a cause of pathology. He also described gastric ulceration due to excess acid production and primary axillary vein thrombosis in 1816[1]. His most important work was Anatomie pathologique du corps humain in two volumes(1829–42). His name is associated with at least four anatomical structures (scaphoid fossa, superficial fascia of perineum, median atlanto-axial joint, posterior cervical plexus), Cruveilhier's sign (persistent hypertension,and portal vein thrombosis), Cruveilheir's atrophy (progressive muscular atrophy, Cruveilheir's cirrhosis (congenital cirrhosis of the liver) and Cruveilhier-Baumgarten disease (Pégot-Cruveilhier-Baumgarten disease, cirrhosis without ascites).


  1. Cruveilhier LJB. Essai sur l’anatomie pathologique en général et sur les transformations et productions organiques en particulier. Doctoral thesis. 2 volumes, Paris, 1816.
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