Lepirudin

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Contents

Introduction

Recombinant analogue of hiridin, a leech protein.

Clinical Use

Indications

Administration

IV

Clinical Issues

The main problems are:

  • Antibody development in 30% on first exposure and 70% on repeat exposure.
  • Bleeding - original dose recommendations probably inappropriate in renal failure or the elderly. -over 1% death rate from bleeding in initial use.

Contra-indications

Cautions and Interactions

Side effects

Special advice

Monitor APTT 2 hours after each dose adjustment

Pharmacology