- Regulation of body weight
- Inhibits food intake
- Stimulates energy expenditure
- Regulation of:
- Inhibits bone formation
Deficiency causes severe hereditary obesity(Leptin deficiency (LEPD, OMIM:614962) and is treatable with leptin. Abnormalities of the leptin receptor are commoner, with perhaps sometimes milder presentations. Such genetic presentations account for up to perhaps 5% of early onset obesity.
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- ↑ Gibson WT, Farooqi IS, Moreau M, DePaoli AM, Lawrence E, O'Rahilly S, Trussell RA. Congenital leptin deficiency due to homozygosity for the Delta133G mutation: report of another case and evaluation of response to four years of leptin therapy. The Journal of clinical endocrinology and metabolism. 2004 Oct; 89(10):4821-6.(Link to article – subscription may be required.)
- ↑ Farooqi IS, Keogh JM, Kamath S, Jones S, Gibson WT, Trussell R, Jebb SA, Lip GY, O'Rahilly S. Partial leptin deficiency and human adiposity. Nature. 2001 Nov 1; 414(6859):34-5.(Link to article – subscription may be required.)