Let nature take its course experiments
In Boston around 1721 there was argument over variolation with churchmen on both sides "...within a year or two after the first experiment nearly three hundred persons had been inoculated by Boylston in Boston and neighbouring towns, and out of these only six had died; whereas, during the same period, out of nearly six thousand persons who had taken smallpox naturally, and had received only the usual medical treatment, nearly one thousand had died."
|Variolated||C 300||6||C 2%|
|Unvariolated||C 6000||C 1000||C 14%*|
gives it as about 14% rather than 17%, likely with closer figures.
- ↑ A HISTORY OF THE WARFARE OF SCIENCE WITH THEOLOGY IN CHRISTENDOM Andrew Dickson White.