Folinic acid

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Contents

Introduction

Antidote to methotrexate. Used in "folinate rescue" in chemotherapy. It is also used to enhance the cytotoxic effects of fluorouracil.

Clinical Use

Indications

  • Chemotherapy

Administration

IV

Clinical Issues

Contra-indications

Cautions and Interactions

Side effects

  • Pyrexia

Special advice

Pharmacology

  • Formyl derivative of tetrahydrofolic acid so is the the active form of folic acid.
  • Combination of folinate with fluorouracil results in the formation of a stable ternary complex consisting of thymidilate synthetase, 5-fluorodeoxy-uridinemonophosphate and 5,10-methylenetetrahydrofolate