Breast lobular carcinoma-in-situ

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A form of intraepithelial neoplasia arising from the epithelium of the lobules of the breast. By definition it does not penetrate the basement membrane compared to lobular carcinoma.

Data are hard to come by but it is thought that at the worst case LCIS may have a relative risk of developing invasive breast cancer of either breast 7-9x that of the general population.

Unlike ductal carcinoma-in-situ there is little evidence that aggressive treatment (Wide local excision or mastectomy) of LCIS in the absence of invasive carcinoma is beneficial. Some evidence is emerging that treatment with tamoxifen may reduce the development of invasive cancer but this has to be balanced against the risks of this treatment.


Guidelines from the Australian National Breast Cancer Centre