Codes for melanocortin 4 receptor at 18q22. Mutations are responsible for autosomal dominant obesity which explains 6% odd of early onset obesity and about 2.5% of adult obesity. As the gene product also has a role in blood pressure regulation patients do not have the hypertension usually associated with their degree of obesity.
- ↑ Greenfield JR, Miller JW, Keogh JM, Henning E, Satterwhite JH, Cameron GS, Astruc B, Mayer JP, Brage S, See TC, Lomas DJ, O'Rahilly S, Farooqi IS. Modulation of Blood Pressure by Central Melanocortinergic Pathways. The New England journal of medicine. 2008 Dec 17.(Epub ahead of print) (Link to article – subscription may be required.)