MRNA vaccine

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mRNA vaccines utilise mRNA to generate a antigen protein within the cytosol of an eukaryote cell. Although they work well in animal models experience with these in man suggest low ability to induce immunity. They were first developed as a form of immunotherapy against some cancers[1][2], and then directed at virus surface proteins such as with the development of a mRNA-based vaccine encoding rabies virus glycoprotein (CV7201)[3]. Development suggests to date that injector devices may create better immunogenicity than the classic IM or s/c injection technique of other vaccines and the vaccine technology allows rapid development cycles and negligible risk of incorporation into the genome as with DNA vaccines or the one shot implication of viral vector vaccines.[4]