MRN complex

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The MRN complex does double-strand DNA break repair in DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. It is composed of:

  1. Double-strand break repair protein MRE11A
    • Single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity
  2. DNA repair protein RAD50
    • Binds DNA ends and hold them in close proximity
  3. Nibrin
    • Modulates the DNA damage signal sensing
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