Memory B lymphocyte
Memory B lymphocytes (more usually termed memory B-cells) are long-lived, pre-stimulated B lymphocytes that are primed for rapid response to a repeat exposure to the priming antigen. Memory B cells are generated, usually in the lymphoid tissue after B cell activation/proliferation and reside in the bone marrow, lymph nodes, and spleen. High affinity surface immunoglobulins enable their activation by lower levels of cognate antigen than are naive B cells. There levels seem to be mainly determined by the anti-apoptotic induced myeloid leukemia cell differentiation protein Mcl-1 (Mcl-1). Loss of peripheral CD27+ memory B cells is a key hall mark of HIV-1 infection and accordingly is relatively well understood. Splenectomy results in depletion of IgM memory B cells and so these cells are important in the immune response against encapsulated bacteria such as Streptococcus pneumoniae, Haemophilus influenzae and Neisseria meningitidis.
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- ↑ Vikstrom I, Carotta S, Lüthje K, Peperzak V, Jost PJ, Glaser S, Busslinger M, Bouillet P, Strasser A, Nutt SL, Tarlinton DM. Mcl-1 is essential for germinal center formation and B cell memory. Science (New York, N.Y.). 2010 Nov 19; 330(6007):1095-9.(Link to article – subscription may be required.)
- ↑ van Grevenynghe J, Cubas RA, Noto A, DaFonseca S, He Z, Peretz Y, Filali-Mouhim A, Dupuy FP, Procopio FA, Chomont N, Balderas RS, Said EA, Boulassel MR, Tremblay CL, Routy JP, Sékaly RP, Haddad EK. Loss of memory B cells during chronic HIV infection is driven by Foxo3a- and TRAIL-mediated apoptosis. The Journal of clinical investigation. 2011 Oct 3; 121(10):3877-88.(Link to article – subscription may be required.)
- ↑ Cameron PU, Jones P, Gorniak M, Dunster K, Paul E, Lewin S, Woolley I, Spelman D. Splenectomy associated changes in IgM memory B cells in an adult spleen registry cohort. PloS one. 2011; 6(8):e23164.(Link to article – subscription may be required.)