Developed by the Czech scientist Frank A. Berger as a muscle relaxant he discovered serendipitously that the laboratory animals he was working on no longer threatened to bite him. It was marketed as a muscle relaxant and shortly after as a tranquilizer in 1955.
Very rarely used now because of its dependence potential it was the wonder drug of the late 1950s.
- First specific anxiolytic
- First commercial drug used to treat hypertension
- Used as a sedative to replace barbituates when their dependence potential was causing concern
- Used as a muscle relaxant. (in Equagesic® until 1992 in UK)
- Anxiety(Short term use)
Oral 200mg tds to 400mg qds in adults.
Cautions and Interactions
- Respiratory disease