Meprobamate
From Ganfyd
rINN: Meprobamate
Other Names
Equanil®, Miltown®
Pharmacological Information
Pharmacology Images
Web information on Meprobamate
Relevant Clinical Literature
UK Guidance
Regulatory Literature
Other Literature
Please read pharmacological data limitations
Other Wikis
Medpedia on Meprobamate (Less technical, good quality control)
Wikipedia on Meprobamate (Less technical, ? quality control)
Contents |
Introduction
Developed by the Czech scientist Frank A. Berger as a muscle relaxant he discovered serendipitously that the laboratory animals he was working on no longer threatened to bite him.[1] It was marketed as a muscle relaxant and shortly after as a tranquilizer in 1955.
In January 2012 the EMA recommended the suspension of all marketing authorisations for oral medicines containing meprobamate
Clinical Use
Very rarely used now because of its dependence potential it was the wonder drug of the late 1950s.
- First specific anxiolytic
- First commercial drug used to treat hypertension
- Used as a sedative to replace barbituates when their dependence potential was causing concern
- Used as a muscle relaxant. (in Equagesic® until 1992 in UK)
Indications
- Anxiety(Short term use)
Administration
Oral 200mg tds to 400mg qds in adults.
Clinical Issues
Contra-indications
Cautions and Interactions
- Respiratory disease
Side effects
- Drowsiness
- Hypotension
