Methadone

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The doctor signing the prescription is liable for the outcome. Beware.

Contents

Introduction

Methadone is an opioid analgesic

Clinical Use

Its use has been promoted as a second line opioid because of its clean metabolism, although it has the potential because of its long half life for accumulation[1]

Indications

  • Moderate-severe pain
  • Opiate substitution

Administration

Oral


IV

Clinical Issues

Toxicity

Contra-indications

Cautions and Interactions

Can cause QT prolongation especially at high doses. Administration by the clock can produce accumulation

Side effects

  • Nausea and vomiting
  • Constipation
  • Drowsiness
  • Respiratory depression
  • Dependence
  • Hallucinations & Confusion

Special advice

As a guide at low doses of the respective narcotics 1ml of methadone mixture 1mg/ml is equivalent to

Please refer to more detailed guidelines as the ratios change with higher and repeated dosing with much less methadone needed[2][3]

Pharmacology

Peak effect 60-300 min, half life 12-18 hour after single dose, up to 60 hours after multiple doses. Metabolism is highly individual

External Links

References

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