Common drug of abuse as hallucinogen. Causes long-lasting changes in brain serotonergic systems that may be clinically significant. A cause of serotonin syndrome and idiosyncratic severe reactions including disseminated intravascular coagulation and hepatitis.
Recreational doses are typically in the region of 1-2mg/kg, resulting in blood levels of 0.01 to 0.35μg/ml. Fatal toxicities have been associated with levels of 0.6 to 3.6μg/ml.
- ↑ Murphy PN, Bruno R, Ryland I, Wareing M, Fisk JE, Montgomery C, Hilton J. The effects of 'ecstasy' (MDMA) on visuospatial memory performance: findings from a systematic review with meta-analyses. Human psychopharmacology. 2012 Mar; 27(2):113-38.(Link to article – subscription may be required.)
- ↑ Di Iorio CR, Watkins TJ, Dietrich MS, Cao A, Blackford JU, Rogers B, Ansari MS, Baldwin RM, Li R, Kessler RM, Salomon RM, Benningfield M, Cowan RL. Evidence for chronically altered serotonin function in the cerebral cortex of female 3,4-methylenedioxymethamphetamine polydrug users. Archives of general psychiatry. 2012 Apr; 69(4):399-409.(Link to article – subscription may be required.)
- ↑ Nadkarni GN, Hoskote SS, Piotrkowski J, Annapureddy N. Serotonin Syndrome, Disseminated Intravascular Coagulation, and Hepatitis After a Single Ingestion of MDMA in an Asian Woman. American journal of therapeutics. 2012 Jun 16.(Epub ahead of print) (Link to article – subscription may be required.)