Category:Monoamine oxidase inhibitors

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Contents

History

Chemistry

Mechanism of action

Pharmacokinetics and pharmacodynamics

Interactions

The most important interaction with food or drugs is life threatening serotonin syndrome. This happens with all type A inhibitors and at high dose with selegiline or linezolid. It classically occurs with blue cheese, and drugs including:

  • Tricyclic antidepressants (TCAs)
  • Selective serotonin re-uptake inhibitors (SSRIs)
  • Pethidine, tramadol and some other narcotic analgesics
  • Over the counter cough medicines
  • Anti-migraine drugs,
  • Weight reduction agents
  • Anti-emetics
  • Drugs of abuse and herbal products such as and pethidine

Opioids

While most, if not all manufactures advise to avoid, serious interaction has not yet been reported for some opioids such as buprenorphine. Pethidine and tramadol are definitely contraindicated as case reports of serotonin syndrome exist. The interaction can be either: The interaction between MAOIs and narcotic analgesics can take on either of two distinctive forms (1,2,3):


Individual MAOIs

  • Standard MAOIs
  1. Phenelzine
  2. Isocaroxazid
  3. Tranylcypromine
  • Reversible MAOIs (also known as RIMAs)
  1. Moclobemide

Subcategories

This category has the following 2 subcategories, out of 2 total.

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Pages in category "Monoamine oxidase inhibitors"

The following 5 pages are in this category, out of 5 total.

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