Mouth ulcer

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Mouth ulcer on lower lip.

Aphthous ulcers in the mouth are common. They are also commonly recurrent.[1]

An ulcer is a breach in the epithelium. This exposes the nerve endings in the lamina propria beneath to the saliva, which may periodically contain irritants, which produce considerable pain.

The causes are unclear although they are associated with some systemic conditions[2], many treatments have been suggested and there is evidence for effectiveness of some of them.




With RCT evidence available

  • Chlorhexidine gluconate mouth rinses reduce the severity of each episode of ulceration, but do not reduce recurrences.
RCTs found that chlorhexidine reduced the mean severity of pain compared with an inert preparation.
  • Topical corticosteroids
Small RCTs found that topical corticosteroids reduced the number of ulcer days compared with control preparations. They also don't prevent more ulcers. They may reduce the duration and pain of ulcers and hasten pain relief without causing notable local or systemic adverse effects.
  • Hexitidine On limited RCTs it probably doesn't work.[6]

This article is a work in progress. Please feel free to contribute to it.


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