Multifocal acquired demyelinating sensory and motor neuropathy
Multifocal acquired demyelinating sensory and motor neuropathy (MADSAM, Lewis-Sumner syndrome, LSS) is a multifocal but asymmetric demyelinating neuropathy with rare axonal degeneration. It is an inflammatory polyradiculoplexoneuropathy that shares features observed in chronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN). It needs to be distinguished from MMN as this has treatment implications as MNN does not ever respond to steroids and may get worse. Short term response with intravenous immunoglobulin is likely to be similar to plasma exchange.. Corticosteroids and immunosuppressive agents might be considered.
- ↑ Saperstein DS, Amato AA, Wolfe GI, Katz JS, Nations SP, Jackson CE, Bryan WW, Burns DK, Barohn RJ. Multifocal acquired demyelinating sensory and motor neuropathy: the Lewis-Sumner syndrome. Muscle & nerve. 1999 May; 22(5):560-6.
- ↑ Viala K, Renié L, Maisonobe T, Béhin A, Neil J, Léger JM, Bouche P. Follow-up study and response to treatment in 23 patients with Lewis-Sumner syndrome. Brain : a journal of neurology. 2004 Sep; 127(Pt 9):2010-7.(Link to article – subscription may be required.)
- ↑ Comi G, Nemni R, Amadio S, Galardi G, Leocani L. Intravenous immunoglobulin treatment in multifocal motor neuropathy and other chronic immune-mediated neuropathies. Multiple sclerosis (Houndmills, Basingstoke, England). 1997 Apr; 3(2):93-7.
- ↑ DNUK posting (membership required).