Multifocal motor neuropathy
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Web Resources for Multifocal motor neuropathy
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Medpedia on Multifocal motor neuropathy (Less technical, good quality control)
Wikipedia on Multifocal motor neuropathy (Less technical, ? quality control)
Multifocal motor neuropathy is an autoimmune condition affecting lower motor neurons only with characteristic EMG findings of conduction blocks. IgM anti-GM1 ganglioside antibodies may be positive. Unlike motor neurone disease it is treatable. However its treatment may differ from that of a closely related condition multifocal acquired demyelinating sensory and motor neuropathy which is steroid responsive and not associated with anti-GM1 antibodies.
Presentation
- Distal arm muscles
- Distribution may initially be that of peripheral nerves
- Slow progression
- Rarely cranial nerves or Respiratory muscles
Treatment
Immunomodulatory therapy with:
Note that steroids have caused deterioration.
