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rINN: Muronomab-CD3
Other Names
OKT-3, Orthoclone OKT3®
Pharmacological Information
Web information on Muronomab-CD3
Mechanism of Action
Murine monoclonal antibody to the CD3 antigen of human T cells. Thought to reverse acute transplant rejection by blocking function of all T cells with major roles
Other Issues for Muronomab-CD3
As foreign antibody, cytokine release syndrome contributing to transient acute tubular necrosis and renal dysfunction. Associated with posttransplant lymphoma
Relevant Clinical Literature
UK Guidance
Regulatory Literature
Other Literature
Other Wikis
Wikipedia on Muronomab-CD3 (Less technical, ? quality control)

Muronomab-CD3 (OKD-3) was the first licensed (FDA 1986) therapeutic monoclonal antibody used in transplantation.