Myristoylation

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Myristoylation refers to the covalent attachment of a 14 carbon myristoyl group, derived from myristic acid to the alpha-amino group of an N-terminal glycine residue of a peptide chain. This modification can be important in signal activation and is either done co-translationally or post-translationally by N-myristoyltransferase (NMT). Pathogenicity of many organisms depends upon activation of certain of their peptides by such myristoylation which tends to result in transient membrane association and exposure of kinase sites when this occurs in its signalling role.

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