Number needed to treat

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An EBM term - 'Number Needed to Treat to produce benefit in one.

Paracetamol for headache has an NNT around 2

An effective intervention well-targeted at a clearly defined group should have a low NNT.

Interventions with a high NNT may nevertheless be worth considering and trying. The one who gets the benefit gets the benefit despite however many do not. In that situation, and particularly if there is a big placebo effect or the effect is difficult to determine, the n-of-1 trial is worth considering.

The companion term to NNT is NNH - the Number Needed (to treat) to Harm one patient.

QuotationMarkLeft.png This particular patient is also a former mathematics teacher and has a good grasp of statistics. For example, he was able to learn for himself from thennt com, which provides summaries of evidence-based medicine, that for aspirin there is a 1 in 333 chance and 1 in 77 chance of mortality and non-fatal heart attack benefit, respectively, and for statins a 1 in 83 chance and 1 in 39 chance of mortality and recurrent non-fatal heart attack benefit, respectively. QuotationMarkRight.pngMalhotra and Bailey.[1]]

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