NRTN

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Web Resources for NRTN


Genetic Databases
GENE database on NRTN
Online Mendelian Inheritance in Man (OMIM) on NRTN
Pharmacogenomics Knowledge Base (pharmGKB) on NRTN
Catalogue Of Somatic Mutations In Cancer (COSMIC) on NRTN
Genome information (GenomeNet, KEGG) on NRTN
SNP database on NRTN
Protein Knowledgebase (UniProtKB) on NRTN
Relevant Clinical Literature
Pubmed on NRTN
RCT with NRTN
Systematic reviews of NRTN
NRTN in N Eng J Med, Lancet, JAMA, BMJ
NRTN in Cochrane Collaboration
TRIP Database on NRTN
Google Scholar on NRTN
Bandolier on NRTN
UK Guidance
NHS Evidence on NRTN
Centre for Reviews and Dissemination databases -DARE & NHS EED (evaluates reliability of research)
Nice Guidance on NRTN
Prodigy Guidance on NRTN
Other Wikis
Medpedia on NRTN (Less technical, good quality control)
Wikipedia on NRTN (Less technical, ? quality control)
Neurturin is a neurotrophic peptide encoded by the NRTN gene at 19p13.3. It is known to support the survival of sympathetic neurons. It can be deficient in Hirschsprung disease[1]. It is being tried as a therapy in advanced Parkinsons disease for example being introduced via an adeno-associated type-2 vector[2].

References

  1. ↑ Doray B, Salomon R, Amiel J, Pelet A, Touraine R, Billaud M, Attié T, Bachy B, Munnich A, Lyonnet S. Mutation of the RET ligand, neurturin, supports multigenic inheritance in Hirschsprung disease. Human molecular genetics. 1998 Sep; 7(9):1449-52.
  2. ↑ Marks WJ, Bartus RT, Siffert J, Davis CS, Lozano A, Boulis N, Vitek J, Stacy M, Turner D, Verhagen L, Bakay R, Watts R, Guthrie B, Jankovic J, Simpson R, Tagliati M, Alterman R, Stern M, Baltuch G, Starr PA, Larson PS, Ostrem JL, Nutt J, Kieburtz K, Kordower JH, Olanow CW. Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial. Lancet neurology. 2010 Oct 20.(Epub ahead of print) (Link to article – subscription may be required.)
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