Naltrexone

From Ganfyd

rINN: Naltrexone

Other Names

Naltrexone hydrochloride, Nalorex^®

Naltrexone Molecule

Pharmacological Information

Pharmacology Images

Web information on Naltrexone

NHS Evidence on Naltrexone

DrugBank on Naltrexone

Relevant Clinical Literature

Pubmed on Naltrexone

RCT with Naltrexone

Systematic reviews of Naltrexone

Naltrexone in N Eng J Med, Lancet, JAMA, BMJ

Naltrexone in Cochrane Collaboration

TRIP Database on Naltrexone

Google Scholar on Naltrexone

Bandolier on Naltrexone

UK Guidance

SNOMED search

Nice Guidance on Naltrexone

BNF-registration required
BNF for children-registration required

UK directory of medicines

UK Medicine Guide (eg pictures of capsules)

Centre for Reviews and Dissemination databases -DARE & NHS EED (evaluates reliability of research)

Prodigy Guidance on Naltrexone

Regulatory Literature

UK SPCs of medicines with marketing authorisation

EMEA search

FDA search

Other Literature

PubChem on Naltrexone

CTD (Comparative Toxicogenomics Database) link

ChemIndustry.com link

Protein Structural Information

Biological Information (GenomeNet)

Protein Knowledgebase (UniProtKB)

Please read pharmacological data limitations

Other Wikis

Medpedia on Naltrexone (Less technical, good quality control)

Wikipedia on Naltrexone (Less technical, ? quality control)

Naltrexone is an opioid antagonist. It is also being developed for various indications, including obesity, when combined with bupropion (as in contrave^®).

Clinical Use

Indications

• Reversal of opioid overdose or toxicity.
• Adjunct to prevent relapse in former opioid dependent patients (opioid free for at least a week) - EU

Administration

IV or IM

Clinical Issues

Toxicity

Contra-indications

• Active opioid dependence
• Acute hepatitis

Cautions and Interactions

Side effects

• Will reverse analgesic effect
• Nausea & vomiting
• Abdominal pain
• Anxiety
• Aches & pains
• Occasional wider range of minor symptoms
• Rarely ITP, rash, LFT abnormalities

Special advice

Pharmacology