Neomycin
From Ganfyd
rINN: Neomycin
Pharmacological Information
Pharmacology Images
Web information on Neomycin
Mechanism of Action
Interferes with (bacterial) protein synthesis
Relevant Clinical Literature
UK Guidance
Regulatory Literature
Other Literature
Please read pharmacological data limitations
Other Wikis
Medpedia on Neomycin (Less technical, good quality control)
Wikipedia on Neomycin (Less technical, ? quality control)
Contents |
Introduction
A natural group of three aminoglycosides from Streptomyces fradiae isolated first in 1949 it is effective against both gram positive and gram negative bacteria. It has high human systemic toxicity.
Clinical Use
Poorly absorbed so widely used for gut sterilisation or topically.
Indications
Administration
Oral Topical
Clinical Issues
Class Contraindications
Class Side-effects
- Ototoxicity
- Nephrotoxicity
- Impairment neuromuscular transmission
Aminoglycoside ototoxicity is associated with a genetic susceptibility in a third to a half of all cases. Most commonly mitochondrial – shows bacterial origin. Screening patients likely to need repeated courses eg CFs, chemotherapy patients, preterm neonates is feasible, but cost:benefit ratio? Consider costs of deafness, cochlear implant etc.
Class Interactions
- Enhanced ototoxicity with ototoxic diuretics eg furosemide.
