Neurturin is a neurotrophic peptide encoded by the NRTN gene at 19p13.3. It is known to support the survival of sympathetic neurons. It can be deficient in Hirschsprung disease. It is being tried as a therapy in advanced Parkinsons disease for example being introduced via an adeno-associated type-2 vector.
- ↑ Doray B, Salomon R, Amiel J, Pelet A, Touraine R, Billaud M, Attié T, Bachy B, Munnich A, Lyonnet S. Mutation of the RET ligand, neurturin, supports multigenic inheritance in Hirschsprung disease. Human molecular genetics. 1998 Sep; 7(9):1449-52.
- ↑ Marks WJ, Bartus RT, Siffert J, Davis CS, Lozano A, Boulis N, Vitek J, Stacy M, Turner D, Verhagen L, Bakay R, Watts R, Guthrie B, Jankovic J, Simpson R, Tagliati M, Alterman R, Stern M, Baltuch G, Starr PA, Larson PS, Ostrem JL, Nutt J, Kieburtz K, Kordower JH, Olanow CW. Gene delivery of AAV2-neurturin for Parkinson's disease: a double-blind, randomised, controlled trial. Lancet neurology. 2010 Oct 20.(Epub ahead of print) (Link to article – subscription may be required.)