Vitamin D3 receptor
The VDR gene at 12q12-q14 codes for the 427 amino acid peptide vitamin D3 receptor. This is a transcription factor that regulates transcription of vitamin D3 sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. In man 2776 genomic positions can be occupied by the receptor which modulates expression in 229 genes. These genes include those implicated in diseases such as multiple sclerosis (IRF8) and Crohn's disease (PTPN2). Calcitriol binds the homodimer receptor, allowing to to become a heterodimer, formed with retinoid X receptor (RXR). This then binds specific genomic sequences called vitamin D response elements (VDREs) which act to influence gene transcription.
- ↑ Ramagopalan SV, Heger A, Berlanga AJ, Maugeri NJ, Lincoln MR, Burrell A, Handunnetthi L, Handel AE, Disanto G, Orton SM, Watson CT, Morahan JM, Giovannoni G, Ponting CP, Ebers GC, Knight JC. A ChIP-seq defined genome-wide map of vitamin D receptor binding: associations with disease and evolution. Genome research. 2010 Oct; 20(10):1352-60.(Link to article – subscription may be required.)
- ↑ Zella LA, Meyer MB, Nerenz RD, Lee SM, Martowicz ML, Pike JW. Multifunctional enhancers regulate mouse and human vitamin D receptor gene transcription. Molecular endocrinology (Baltimore, Md.). 2010 Jan; 24(1):128-47.(Link to article – subscription may be required.)