Oestrogen receptor beta
The ESR2 gene at 14q23.2-q23.3 codes for the 530 amino acid oestrogen receptor beta. It can form heterodimers with oestrogen receptor alpha and is also a member of the family of oestrogen receptors which are nuclear receptor transcription factors. The peptide contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or other oestogens the protein dimers interact with specific DNA sequences to activate transcription. Some of the six isoforms, such as isoform 2 dominantly inhibit the DNA binding of oestrogen receptor alpha when combined in a heterodimer with it. These alternatively spliced transcript variants of this gene have differential tissue expression.