Orexin-A

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Cleavage product (AA 34 – 66) of the 161 aminio acid propeptide orexin coded by the HCRT gene. It binds to both the orexin receptor type 1 and the orexin receptor type 2 with a high affinity and so has a role in the regulation of sleep, appetite and probably autonomic function, hormonal balance and the regulation of fluid balance. Absent or very low levels are found in the cerebrospinal fluid in most patients with narcolepsy.

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