Orexin-B

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Common Name:Orexin-B
Other Names, such as IUPAC Name
Orexin-B, orexin-2, hypocretin-2, Hcrt2
Biochemical Information
Molecular Structure
PubChem on Orexin-B
CTD (Comparative Toxicogenomics Database) on Orexin-B
Chemical Information on Orexin-B
Protein Structural Information on Orexin-B
Biological Information (GenomeNet) on Orexin-B
Protein Knowledgebase (UniProtKB) on Orexin-B
Online Mendelian Inheritence in Man (OMIM) on Orexin-B
Important Issues in Man
Data limitations
Relevant Clinical Literature
Pubmed on Orexin-B
RCT with Orexin-B
Systematic reviews of Orexin-B
Orexin-B in N Eng J Med, Lancet, JAMA, BMJ
Orexin-B in Cochrane Collaboration
TRIP Database on Orexin-B
Google Scholar on Orexin-B
Bandolier on Orexin-B
UK Guidance
NHS Evidence on Orexin-B
Centre for Reviews and Dissemination databases -DARE & NHS EED (evaluates reliability of research)
Nice Guidance on Orexin-B
Prodigy Guidance on Orexin-B
Other Wikis
Medpedia on Orexin-B (Less technical, good quality control)
Wikipedia on Orexin-B (Less technical, ? quality control)

Cleavage product (AA 70 – 97) of the 161 aminio acid propeptide orexin coded by the HCRT gene. It binds to the orexin receptor type 2 with a high affinity and so has a role in the regulation of sleep. Some mammals such as cattle get by with only effectively orexin-A. Absent or very low levels are found in the cerebrospinal fluid in most patients with narcolepsy. Orexin-2 receptor antagonists initiate sleep and prolong sleep in the sleep-awake structures of the lateral hypothalamus.

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