Osteoclast
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Osteoclasts are a bone cell type key to bone resorption that produces the enzymes necessary for bone remodelling. They were discovered by Albert von Kölliker in 1873 with their characteristic multiple closely packed oval-shaped nuclei. Cell lineage is related to monocytes and macrophages with high expression of tartrate resistant acid phosphatase (TRAP) and cathepsin K. Formation of osteoclasts is promoted by receptor activator of nuclear factor κβ and M-CSF.
