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Cancer affecting the ovaries.
Diagnosis of ovarian cancerScreening for this cancer is not recommended, as the tests available do not meet the criteria for a screening test. Recommendations on the use of the CA125 tumour marker, was published by NICE in 2011.
NICE presented a risk of malignancy index calculation and suggest referral for women with a score of 250 or above.
Risk of malignancy index I (RMI I) RMI I is a product of the ultrasound scan score (U), menopausal status (M) and serum CA125 level. RMI I = U * M * CA125
The ultrasound result is scored 1 point for each of the following characteristics:- multilocular cysts, solid areas, metastases, ascites bilateral lesions.
U = 0 for an ultrasound score of 0 points, U = 1 for an ultrasound score of 1 point, U = 3 for an ultrasound score of 2–5 points.
Menopausal status is scored as 1 = pre-menopausal and 3 = post-menopausal.
‘post-menopausal’ is taken to be a woman who has had no period for more than 1 year or a woman over 50 who has had a hysterectomy.
Serum CA125 is measured in IU/ml.