Programmed cell death protein 1

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Common Name:Programmed cell death protein 1
Other Names, such as IUPAC Name
Programmed death 1, protein PD-1, hPD-1, PD-1, CD279
Biochemical Information
Molecular Structure
Important Issues in Man
Relevant Clinical Literature
UK Guidance
Other Wikis
Wikipedia on Programmed cell death protein 1 (Less technical, ? quality control)
Programmed cell death protein 1 is coded by the PDCD1 gene at 2q37.3 and expressed as a 288 amino acid peptide which is further processed to an inhibitory T cell membrane receptor for the membrane signal proteins programmed cell death 1 ligand 1 and programmed cell death 1 ligand 2. It has critical roles in immunity influencing response to autoimmune disease, infections, transplantation. allergy and malignancy. Inhibition has been used in effective immunotherapy for melanoma and small cell lung cancer.

Variants in the PDCD1 are associated with susceptibility to systemic lupus erythematosus type 2 and disease progression in multiple sclerosis.

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