- PlGF-1 is found as an antiparallel disulfide-linked homodimer
- Also expressed by colon and mammary carcinomas
- PlGF-2 is found as an antiparallel disulfide-linked homodimer
- PlGF-3 is found both as homodimer and as monomer
The chain also forms dimers with VEGF. It is involved in angiogenesis and endothelial cell proliferation and migration. It binds to the receptor FLT1/VEGFR-1. and is part of the vascular endothelial growth factor family. Produced by placental trophoblastic tissue. Used as a screening test for Down's syndrome.