PGF

Placenta growth factor is a peptide chain of 221 amino acids coded by PGF gene at 14q24-q31 with three isoforms that once N-glycosylated is expressed by most placental tissues and that may be secreted:

PlGF-1 is found as an antiparallel disulfide-linked homodimer
- Also expressed by colon and mammary carcinomas
PlGF-2 is found as an antiparallel disulfide-linked homodimer
- Remains cell attached unless released by heparin
- Binds NRP1/neuropilin-1 and NRP2/neuropilin-2 in a heparin-dependent manner
- Specific to early placenta up to 8 weeks
PlGF-3 is found both as homodimer and as monomer

The chain also forms dimers with VEGF. It is involved in angiogenesis and endothelial cell proliferation and migration. It binds to the receptor FLT1/VEGFR-1. and is part of the vascular endothelial growth factor family. Produced by placental trophoblastic tissue. Used as a screening test for Down's syndrome.^[1]

References

↑ Debieve F, Moiset A, Thomas K, Pampfer S, Hubinont C. Vascular endothelial growth factor and placenta growth factor concentrations in Down's syndrome and control pregnancies. Molecular human reproduction. 2001 Aug; 7(8):765-70.

[0] Debieve F, Moiset A, Thomas K, Pampfer S, Hubinont C. Vascular endothelial growth factor and placenta growth factor concentrations in Down's syndrome and control pregnancies. Molecular human reproduction. 2001 Aug; 7(8):765-70.

[1]

PGF

From Ganfyd

References

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