Paclitaxel

From Ganfyd

rINN: Paclitaxel

Other Names

Taxol^® (Abraxane^® is praclitaxel that is albumin bound)

Pharmacological Information

Pharmacology Images

Paclitaxel Molecule

Paclitaxel in the:

BNF-registration required
BNF for children-registration required

DrugBank on Paclitaxel

PubDrug on Paclitaxel

UK SPCs of medicines with marketing authorisation

UK directory of medicines

UK Medicine Guide (eg pictures of capsules)

Relevant Clinical Literature

Pubmed on Paclitaxel

NHS Evidence on Paclitaxel

RCT with Paclitaxel   from Pubmed

Systematic reviews   from Pubmed

TRIP Database on Paclitaxel

N Eng J Med, Lancet,JAMA, BMJ   from Pubmed

Cochrane Collaboration   from Pubmed

Google Scholar on Paclitaxel

Other Literature

PubChem on Paclitaxel

CTD (Comparative Toxicogenomics Database) link

ChemIndustry.com link

Protein Structural Information

Biological Information (GenomeNet)

Protein Knowledgebase (UniProtKB)

Please read pharmacological data limitations

Introduction

The native drug has solubility and hypersensivity issues with markedly lower response rate than the more expensive albumin bound form.

Clinical Use

Metastatic breast cancer

Indications

• Ovarian cancer
• Metastatic breast cancer
• Kaposi's sarcoma - AIDS related
• non-small cell lung cancer

Administration

IV

Clinical Issues

Contra-indications

Cautions and Interactions

Side effects

• Neurotoxin

Special advice

Pharmacology