Paclitaxel

From Ganfyd

rINN: Paclitaxel

Other Names

Taxol^® (Abraxane^® is praclitaxel that is albumin bound)

Pharmacological Information

Pharmacology Images

Paclitaxel Molecule

Web information on Paclitaxel

NHS Evidence on Paclitaxel

DrugBank on Paclitaxel

Relevant Clinical Literature

Pubmed on Paclitaxel

RCT with Paclitaxel

Systematic reviews of Paclitaxel

Paclitaxel in N Eng J Med, Lancet, JAMA, BMJ

Paclitaxel in Cochrane Collaboration

TRIP Database on Paclitaxel

Google Scholar on Paclitaxel

Bandolier on Paclitaxel

UK Guidance

SNOMED search

Nice Guidance on Paclitaxel

BNF-registration required
BNF for children-registration required

UK directory of medicines

UK Medicine Guide (eg pictures of capsules)

Centre for Reviews and Dissemination databases -DARE & NHS EED (evaluates reliability of research)

Prodigy Guidance on Paclitaxel

Regulatory Literature

UK SPCs of medicines with marketing authorisation

EMEA search

FDA search

Other Literature

PubChem on Paclitaxel

CTD (Comparative Toxicogenomics Database) link

ChemIndustry.com link

Protein Structural Information

Biological Information (GenomeNet)

Protein Knowledgebase (UniProtKB)

Please read pharmacological data limitations

Other Wikis

Medpedia on Paclitaxel (Less technical, good quality control)

Wikipedia on Paclitaxel (Less technical, ? quality control)

Introduction

The native drug has solubility and hypersensivity issues with markedly lower response rate than the more expensive albumin bound form.

Clinical Use

Metastatic breast cancer

Indications

• Ovarian cancer
• Metastatic breast cancer
• Kaposi's sarcoma - AIDS related
• non-small cell lung cancer

Administration

IV

Clinical Issues

Contra-indications

Cautions and Interactions

Side effects

• Neurotoxin

Special advice

Pharmacology