Pancreatic polypeptide

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Pancreatic polypeptide (Pancreatic prohormone, PP) is coded for at 17q12-q21 and when cleaved into pancreatic hormone (PH) and pancreatic icosapeptide (PI) mainly released by cells located at the periphery of the pancreatic islets, although some is also released by the exocrine pancreas and distal gut. There is no evidence of CNS production although the vagus nerve does modulate gut production. Human PP exerts an inhibitory effect on gastric emptying, as well as delaying the postprandial rise in insulin and binds to both the Y4 receptor and Y5 receptor. Animal PPs appear to have differing actions.

Prader–Willi syndrome has abnormal circadian rhythm levels of the hormone in the blood. Obinepitide is a closely related drug in development.