Type of secretory epithelial cell found in the small bowel within crypts of Lieberkühn and, to an extent, on the right side of the colon. They are thought to play a role in the innate immunity of the bowel through the production of immunoregulatory and antimicrobial proteins including the defensins. Dysfunction of the Paneth cells has been linked to the inflammatory bowel disease. The presence of Paneth cells in biopsies of the left side of colon is regarded as pathological and due to chronic inflammation.
- ↑ Ayabe T, Satchell DP, Wilson CL, Parks WC, Selsted ME, Ouellette AJ. Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria. Nature immunology. 2000 Aug; 1(2):113-8.(Link to article – subscription may be required.)
- ↑ Wehkamp J, Salzman NH, Porter E, Nuding S, Weichenthal M, Petras RE, Shen B, Schaeffeler E, Schwab M, Linzmeier R, Feathers RW, Chu H, Lima H, Fellermann K, Ganz T, Stange EF, Bevins CL. Reduced Paneth cell alpha-defensins in ileal Crohn's disease. Proceedings of the National Academy of Sciences of the United States of America. 2005 Dec 13; 102(50):18129-34.(Link to article – subscription may be required.)