Periodic syndrome

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A variety of diseases cause recurring fever, including a range of infections and many inflammatory diseases. First named as such in 1933 it was described by Gee in 1882 [1].

A subgroup have related features, and are sometimes called autoinflammatory conditions, as there is no identified autoantibody

have a number of common features eg serositis causing chest or abdominal pain, arthralgia, but have now had their specific genetic mutations identified. Some of these conditions have mutations that are strongly linked to specific ethnic groups, others do not. Other features are particular to the individual condition and may give a clue to the diagnosis. However, many of these mutations poorly penetrate and this can lead to considerable clinical variation.

Another subgroup of conditions exists where there is a cryopyrin defect. There is little overlap here:

References

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