Plasma cell

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Plasma cells. Some are binucleate. The nuclei are classically described as resembling a clock-face.

Plasmacytes or "plasma cells" are lymphoid cells of the B-lymphocyte lineage, which are differentiated to antibody, i.e. immunoglobulin) production. They are the cell type involved in myeloma.

Histologically, they are oval cells with an eccentrically-located, round, 'clock face' nuclei, commonly with a perinuclear 'hof' (a small crescentic clearing representing the Golgi apparatus). Aggregates of immunoglobulin can be seen within the plasma cells within the cytoplasm as Russell bodies or, if the cytoplasmic aggregates indent/invaginate the nucleus, as Dutcher bodies.

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