Polycystin-1
From Ganfyd
Common Name:Polycystin-1
Other Names, such as IUPAC Name
Polycystin 1,autosomal dominant polycystic kidney disease 1 protein
Biochemical Information
Molecular Structure
Important Issues in Man
Relevant Clinical Literature
UK Guidance
Other Wikis
Medpedia on Polycystin-1 (Less technical, good quality control)
Wikipedia on Polycystin-1 (Less technical, ? quality control)
It has a LDL-receptor class A domain and is analogous to polycystic kidney disease protein 1-like 3 which complexed with polycystic kidney disease 2-like 1 protein forms one of the acid taste receptors[2][3].
References
- ↑ van Bodegom D, Roessingh W, Pridjian A, El Dahr SS. Mechanisms of p53-mediated repression of the human polycystic kidney disease-1 promoter. Biochimica et biophysica acta. 2010 Apr 11.(Epub ahead of print) (Link to article – subscription may be required.)
- ↑ Kawaguchi H, Yamanaka A, Uchida K, Shibasaki K, Sokabe T, Maruyama Y, Yanagawa Y, Murakami S, Tominaga M. Activation of polycystic kidney disease-2-like 1 (PKD2L1)-PKD1L3 complex by acid in mouse taste cells. The Journal of biological chemistry. 2010 Jun 4; 285(23):17277-81.(Link to article – subscription may be required.)
- ↑ Ishimaru Y, Katano Y, Yamamoto K, Akiba M, Misaka T, Roberts RW, Asakura T, Matsunami H, Abe K. Interaction between PKD1L3 and PKD2L1 through their transmembrane domains is required for localization of PKD2L1 at taste pores in taste cells of circumvallate and foliate papillae. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2010 Jun 10.(Epub ahead of print) (Link to article – subscription may be required.)
