RE1-silencing transcription factor

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Common Name:RE1-silencing transcription factor
Other Names, such as IUPAC Name
REST, Neural-restrictive silencer factor, X2 box repressor
Biochemical Information
Molecular Structure
Important Issues in Man
Relevant Clinical Literature
UK Guidance
Other Wikis
Wikipedia on RE1-silencing transcription factor (Less technical, ? quality control)

RE1-silencing transcription factor is a key zinc finger transcriptional repressor coded for by the REST gene at 4q12-13 which represses neuronal gene transcription in non-neuronal cells. It works by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. There are 4 known isoforms produced by alternate splicing. Isoform 3 is also known as N4. It is known to:

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