RE1-silencing transcription factor
RE1-silencing transcription factor is a key zinc finger transcriptional repressor coded for by the REST gene at 4q12-13 which represses neuronal gene transcription in non-neuronal cells. It works by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. There are 4 known isoforms produced by alternate splicing. Isoform 3 is also known as N4. It is known to:
- Bind to neuron-restrictive silencer element (NRSE)
- Be associated with the corepressors relevant to the function of the histone deacetylase complex, paired amphipathic helix protein Sin3a, paired amphipathic helix protein Sin3b and REST corepressor 1, which acts as the promoter of REST-regulated genes.
- Be expressed abnormally in Down syndrome as a result of the extra copy of its regulator DYRK1A gene.