- Soluble RET kinase fragment
- Extracellular cell-membrane anchored RET cadherin 120 kDa fragment
The enzyme is widely involved in involved in regulating cellular mechanisms including cell proliferation, migration and differentiation as well as neuronal navigation. It phosphorylates PTK2/FAK1. It is inhibited by andetanib, cabozantinib, motesanib, sorafenib, sunitinib, and withaferin A.
Well over 100 variants of RET associated with various diseases are known.
Other genetic conditions due to mutations in RET include renal adysplasia (renal agenesis, renal aplasia, RADYS) and congenital central hypoventilation syndrome (congenital failure of autonomic control, Ondine curse, CCHS).