RNA-induced silencing complex

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The RNA-induced silencing complex (RISC) contains the argonaute protein and is key to siRNA function. The 'minimal RISC' appears to include protein argonaute-2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). The term RISC is also used for the trimeric RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC) which contains endoribonuclease Dicer, protein argonaute-2 and RISC-loading complex subunit TARBP2. The other two proteins preprocess and load RNA for protein argonaute-2 which once primed can act on mRNA by itself with the SiRNA.

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