Marburg virus

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Marburg virus (marburgvirus, MARV), an enveloped, nonsegmented, negative-strand RNA virus, is a feared cause of one of the viral haemorrhagic fevers, Marburg disease. Its reservoir is Rousettus aegyptiacus fruit bats. Outbreaks continue in Africa where it has spread over the last 200 years widely from an Ugandan origin. It is closely related to Ravn virus (RARV) also of the Marburgvirus genus and which seems to have only evolved in the last 30 years in Kenya[1][2]. MARV is divided into two main clades:

  1. Clade A (MARV-Ang, Ci67, Popp, Lake Victoria Marburg complex, Musoke)
    • Isolates from Uganda (1967), Kenya (1980) and Angola (2004-2005)
    • Musoke strain was first isolated in 1980 in Nzoia, Kenya
  2. Clade B (Ravn)
    • Isolates from Congo (1999-2000) and Uganda (2007-2009)
    • MARV-Rav was first isolated in 1987 from a case originating in southeastern Kenya

References