Reibergrams

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or Reiber's quotient diagram are used in CSF analysis. They are much more discriminatory for interpreting differential protein fractions of significance in many CSF diseases as they can be readily divided into 4 zones:

  1. Normal
  2. Blood-CSF (blood-brain) barrier dysfunction only
  3. Increased intrathecal protein synthesis and blood-CSF (blood-brain) barrier dysfunction
  4. Increased intrathecal protein synthesis and normal blood-CSF (blood-brain) barrier function

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