Renal oncocytoma

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Benign tumour of the kidney, accounting for 5-10% of the neoplasm and thought to arise from the intercalated cells of the collecting ducts.

Has a characteristic mahogany cut-surface with a stellate scar. Radiologically, it can be hard to distinguish from renal cell carcinoma.

Histopathology

Photomicrograph of renal oncocytoma.

Shows typical oncocytic cells with finely granular eosinphilic cytoplasm.

  • Nuclei are round with smooth contours and even chromatin
  • Nucleoli can be prominent.
  • Fine delicate fibrotic bands
  • Nearest differential can be eosinophilic variant of renal cell carcinoma, or the chromophobe variant of renal cell carcinoma (rarely, in Birt-Hogg-Dube syndrome, there can be hybrid tumours)