Rifampicin

From Ganfyd

rINN: Rifampicin

Other Names

Rifadin^®, Rimactane^®

Pharmacological Information

Pharmacology Images

Rifampicin Molecule

Rifampicin in the:

BNF-registration required
BNF for children-registration required

DrugBank on Rifampicin

PubDrug on Rifampicin

UK SPCs of medicines with marketing authorisation

UK directory of medicines

UK Medicine Guide (eg pictures of capsules)

Metabolism & Interactions

Inhibition of metabolism of other drugs metabolised by CYP2C8 has caused harm

Mechanism of Action

Rifamycin antibiotic

Other Issues for Rifampicin

Care with contact sensitivity, Also stains everything red

Relevant Clinical Literature

Pubmed on Rifampicin

NHS Evidence on Rifampicin

RCT with Rifampicin   from Pubmed

Systematic reviews   from Pubmed

TRIP Database on Rifampicin

N Eng J Med, Lancet,JAMA, BMJ   from Pubmed

Cochrane Collaboration   from Pubmed

Google Scholar on Rifampicin

Other Literature

PubChem on Rifampicin

CTD (Comparative Toxicogenomics Database) link

ChemIndustry.com link

Protein Structural Information

Biological Information (GenomeNet)

Protein Knowledgebase (UniProtKB)

Please read pharmacological data limitations

Rifamicin is a semisynthetic rifamycin derived from Amycolatopsis mediterranei. It was first marketed in 1966.

It has a useful range of activity allowing it to be used, usually in combination with a wide range of bacterial illness. It is a standard first line therapy for several infections including:

• Staphylococcus aureus
• Tuberculosis
• Brucellosis
• Buruli ulcer
• Meningococcal chemoprophylaxis
• Haemophilus influenzae chemoprophylaxis
• Legionnaire's disease

It has enzyme inducing properties so is used in cholestasis when patients are intolerant to colestyramine.