Web information on Rufinamide
Metabolism & Interactions
Hydrolysis so little hepatic interaction but its serum level is influenced by many other anticonvulsants and it increases phenytoin levels
Mechanism of Action
Modulates sodium channels, prolonging inactive state
Relevant Clinical Literature
Please read pharmacological data limitations
Wikipedia on Rufinamide (Less technical, ? quality control)
- Adjunctive treatment of seizures associated with Lennox-Gastaut syndrome
Oral dose based on age, body weight and concomitant sodium valproate (see manufacturers literature, UK SPC).
Cautions and Interactions
- Contraceptive measures necessary in women
- Interacts with valproate, carbamazepine, phenobarbital, phenytoin, vigabatrin or primidone.