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The CXCL5 gene at 4q13.3 codes for C-X-C motif chemokine 5 a 114 amino acid peptide that is further processed before release. It is the chemokine that appears to mediate pain in sunburn[1] and some other forms of local tissue injury and activates neutrophils. There are cleavage sites at amino acids 44 and 45 that produce the peptides ENA-78(8-78) and ENA-78(9-78) which are more biologically active. It has been associated with metastatic malignancy and atherosclerosis. Interleukin-1 or tumour necrosis factor alpha stimulate its secretion by cells, and also production of interleukin-8 which is also coded in the same chromosome region and has some sequence homology.