Salt-inducible kinase

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There are three salt inducable kinases in man:

  1. Serine/threonine-protein kinase SIK1 coded by the SIK1 gene at 21q22.3
    • Involved in cell cycle regulation, gluconeogenesis, lipogenesis , muscle growth and differentiation and tumour suppression.
  2. Serine/threonine-protein kinase SIK2 coded by the SIK2 gene at 11q23.1
  3. Serine/threonine-protein kinase SIK3 coded by the SIK3 gene at 11q23.3

They catalyse ATP + a protein => ADP + a phosphoprotein with Mg2+ as a cofactor.

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