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A chronic condition characterised by non-necrotising granulomas of unknown aetiology. The term sarcoid invented in 1899 by dermatologist Caesar Boeck.


Clinical Features

Diverse with peak incidence in the third decade. There is variation with race and latitude. One of the causes of hilar lymphadenopathy and hypercalcaemia. It is rarely possible to be sure of the diagnosis on clinical grounds without histological evidence, unless a patient presents with Löfgren's syndrome. About 5% get sarcoid of the nervous system (neurosarcoidosis).


Respiratory symptoms present in about 90% of cases.




Nervous system

Rare but serious.

  • Mengio-encephalitis
  • Isolated nerve palsy
  • Neuropathy


Important as always in differential of:


Important as potentially life threatening

  • Arrhythmias


G/I tract

Rarely involved

Differential diagnosis


  • FBC
  • ECr
  • Calcium
  • Immunoglobulins - mainly to exclude common variable immunodeficiency - in sarcoid will have activated immune response
  • Serum ACE is nonspecific and not useful in monitoring disease activity and interpretation is now understood to be modified by polymorphisms. Accordingly it is deprecated
  • Chest X-ray
  • Urine cells & protein
  • Spirometry if chest symptoms
  • ECG for arrhythmia or conduction abnormalities
  • Slit lamp in proven patients to exclude posterior uveitis
  • Biopsy is almost always the only way to define the diagnosis. (Gold standard).

Histological Features

Non-caseating granulomata.

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